Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
نویسندگان
چکیده
Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.
منابع مشابه
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عنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011